Ans: Before reaching the conclusion which type of mutation leads to more devastated result, we must discuss on the differences between points and frame shift mutation are. Point mutation caused by change of single nucleotide by means of base substitution. This can leads to Nonsense, missense or silent mutation. Nonsense mutation results in shortening of peptide by inducing stop codon. Missense alters the actual amino acid and silent has not at all any effect on the peptide. So a point mutation is not always has devastating outcome.