Common manifestation of toxic are described below: 1. Allergy: This is caused by exposure to certain substance like bee venom, pollen that provokes immunity .When body encounter this substances our immune cells produces a protein called antibodies. Sometime our immune system become over active act reacts against harmless substances considering them as allergen. Allergy may be mild to severe like sneezing, itching, conjunctivitis, swelling of lip, face, tongue or throat, oedema, etc. Increased severity may cause anaphylaxis, i.e. loss of consciousness, nausea, vomiting, skin rashes etc.