The opioid crisis refers to a public health emergency characterized by the overuse and abuse of prescription and illicit opioids.Opioid addiction can lead to physical dependence, withdrawal symptoms, and increased tolerance, which can result in overdose and death.The opioid crisis has had significant economic impacts, costing the United States an estimated $78.5 billion annually in healthcare, Opioids include prescription painkillers, heroin, and fentanyl, which can lead to addiction and death. 0